Vascular Endothelial Protein Tyrosine Phosphatase Regulates Endothelial Function

Physiology (Bethesda). 2021 Mar 1;36(2):84-93. doi: 10.1152/physiol.00026.2020.

Abstract

Vascular endothelial protein tyrosine phosphatase (VE-PTP) is a receptor-type PTP (RPTP), predominantly expressed in vascular endothelial cells. It regulates embryonic and tumor angiogenesis and controls vascular permeability and homeostasis in inflammation. Major substrates are the tyrosine kinase receptor Tie-2 and the adhesion molecule VE-cadherin. This review describes how VE-PTP controls vascular functions by its various substrates and the therapeutic potential of VE-PTP in various pathophysiological settings.

Keywords: angiogenesis; endothelial barrier; endothelium; vascular physiology.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Capillary Permeability
  • Endothelial Cells* / metabolism
  • Endothelium, Vascular / metabolism
  • Phosphorylation
  • Receptor-Like Protein Tyrosine Phosphatases, Class 3* / metabolism

Substances

  • Receptor-Like Protein Tyrosine Phosphatases, Class 3