Long intergenic non-coding RNA (lincRNA)-01317 suppresses human gastric cancer growth by inhibiting migration and invasion of cancer cells

Yong Chen; Kundong Zhang; Zhilong Yu; Jinsong Wu; Zhengjun Qiu

Long intergenic non-coding RNA (lincRNA)-01317 suppresses human gastric cancer growth by inhibiting migration and invasion of cancer cells

Am J Transl Res. 2021 Feb 15;13(2):770-780. eCollection 2021.

Authors

Yong Chen^{1

2}, Kundong Zhang³, Zhilong Yu³, Jinsong Wu², Zhengjun Qiu^{1

3}

Affiliations

¹ Department of General Surgery, Shanghai General Hospital of Nanjing Medical University 100 Haining Road, Shanghai 200080, P. R. China.
² Department of General Surgery, Jiuting Hospital of Songjiang District 155 Jiuxin Road, Shanghai 201615, P. R. China.
³ Department of General Surgery, Shanghai General Hospital, Shanghai Jiaotong University 100 Haining Road, Shanghai 200080, P. R. China.

PMID: 33594325
PMCID: PMC7868834

Abstract

Long intergenic noncoding RNAs (lincRNAs) are strongly associated with several kinds of cancer, including gastric cancer. Here, we found significantly decreased lincRNA-01317 levels in cancer tissue compared with paracancer tissue of patients with gastric cancer, and lincRNA-01317 expression levels positively correlated with clinical survival rate. Furthermore, using a gastric cancer cell line and a xenograft mouse model, we found that transfection of a gastric cancer cell line with lincRNA-01317 significantly inhibited the proliferation, migration, and invasion of gastric cancer cells. Finally, we demonstrated that lincRNA-01317 may target KCNQ1, as KCNQ1 was downregulated after transfection of cells with lincRNA-01317. This study aimed to assess lincRNA-01317 as a potential therapeutic target to treat cancers.

Keywords: LincRNA01317; gastric cancer.