Highly efficient sunitinib release from pH-responsive mHPMC@Chitosan core-shell nanoparticles

Hessam Jafari; Gholam Reza Mahdavinia; Bagher Kazemi; Hermann Ehrlich; Yvonne Joseph; Mehdi Rahimi-Nasrabadi

doi:10.1016/j.carbpol.2021.117719

Highly efficient sunitinib release from pH-responsive mHPMC@Chitosan core-shell nanoparticles

Carbohydr Polym. 2021 Apr 15:258:117719. doi: 10.1016/j.carbpol.2021.117719. Epub 2021 Jan 29.

Authors

Hessam Jafari¹, Gholam Reza Mahdavinia², Bagher Kazemi³, Hermann Ehrlich⁴, Yvonne Joseph⁴, Mehdi Rahimi-Nasrabadi⁵

Affiliations

¹ Molecular Biology Research Center, Systems Biology and Poisoning Institute, Baqiyatallah University of Medical Sciences, Sheikh Bahaei Street, Tehran, 1951683759, Iran; Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran.
² Polymer Research Laboratory, Department of Chemistry, Faculty of Science, University of Maragheh, 55181-83111, Maragheh, Iran. Electronic address: grmnia@maragheh.ac.ir.
³ Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran.
⁴ Institute of Electronics and Sensor Materials, TU Bergakademie Freiberg, Gustav Zeuner Str. 3, 09599, Freiberg, Germany.
⁵ Molecular Biology Research Center, Systems Biology and Poisoning Institute, Baqiyatallah University of Medical Sciences, Sheikh Bahaei Street, Tehran, 1951683759, Iran; Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran. Electronic address: rahimi@bmsu.ac.ir.

PMID: 33593581
DOI: 10.1016/j.carbpol.2021.117719

Abstract

This study reports developing novel smart drug delivery systems (DDS) that have great importance in anticancer therapeutics. The magnetic hydroxypropyl methylcellulose (mHPMC) synthesized via in situ method and introduced in the fabrication of tripolyphosphate (TPP)-cross-linked chitosan core-shell nano-carriers (mHPMC@Chitosan). The TPP-cross-linked mHPMC@Chitosan nano-carriers then characterized using TEM, SEM/EDS, DLS, XPS, FTIR, TGA, XRD, and VSM. The encapsulation efficiency showed high capacity of loading for sunitinib malate (above 86 % for all samples). At pH 7.4, the minimum content of drug release was observed for all samples fabricated with variable contents of chitosan. At pH 4.5, the effect of chitosan content revealed that the rate of sunitinib release tends to decrease as its content increased. During two days, 44 and 93 % of the loaded sunitinib released from carriers containing high and low contents of chitosan, respectively. Besides, this mHPMC@Chitosan core shell nano-carrier shown pH-sensitive drug release.

Keywords: Chitosan; Sunitinib; mHPMC; pH-Responsive.