Preparation of cerium molybdates and their antiviral activity against bacteriophage Φ6 and SARS-CoV-2

Takuro Ito; Kayano Sunada; Takeshi Nagai; Hitoshi Ishiguro; Ryuichi Nakano; Yuki Suzuki; Akiyo Nakano; Hisakazu Yano; Toshihiro Isobe; Sachiko Matsushita; Akira Nakajima

doi:10.1016/j.matlet.2021.129510

Preparation of cerium molybdates and their antiviral activity against bacteriophage Φ6 and SARS-CoV-2

Mater Lett. 2021 May 1:290:129510. doi: 10.1016/j.matlet.2021.129510. Epub 2021 Feb 11.

Authors

Affiliations

¹ Department of Materials Science and Engineering, School of Materials and Chemical Technology, Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro-ku, Tokyo 152-8550, Japan.
² Antibacterial and Antiviral Research Group, Kanagawa Institute of Industrial Science and Technology, LiSE4c-1, 3-25-13 Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa 210-0821, Japan.
³ Department of Microbiology and Infectious Diseases, Nara Medical University, 840 Shijo-cho, Kashihara-shi, Nara 634-8521, Japan.

Abstract

Two cerium molybdates (Ce₂Mo₃O₁₂ and γ-Ce₂Mo₃O₁₃) were prepared using either polymerizable complex method or hydrothermal process. The obtained powders were almost single-phase with different cerium valence. Both samples were found to have antiviral activity against bacteriophage Φ6. Especially, γ-Ce₂Mo₃O₁₃ exhibited high antiviral activity against both bacteriophage Φ6 and SARS-CoV-2 coronavirus, which causes COVID-19. A synergetic effect of Ce and molybdate ion was inferred along with the specific surface area as key factors for antiviral activity.

Keywords: Antiviral; Cerium; Complex oxide; Coronavirus; Molybdate.