Neurotrophic factors and their receptors in lung development and implications in lung diseases

Limor Rubin; Collin T Stabler; Adi Schumacher-Klinger; Cezary Marcinkiewicz; Peter I Lelkes; Philip Lazarovici

doi:10.1016/j.cytogfr.2021.01.008

Neurotrophic factors and their receptors in lung development and implications in lung diseases

Cytokine Growth Factor Rev. 2021 Jun:59:84-94. doi: 10.1016/j.cytogfr.2021.01.008. Epub 2021 Feb 5.

Authors

Limor Rubin¹, Collin T Stabler², Adi Schumacher-Klinger³, Cezary Marcinkiewicz⁴, Peter I Lelkes⁵, Philip Lazarovici⁶

Affiliations

¹ Allergy and Clinical Immunology Unit, Department of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. Electronic address: limorlaz@gmail.com.
² Department of Bioengineering, College of Engineering, Temple University, Philadelphia, PA, USA. Electronic address: cstabler@exponent.com.
³ School of Pharmacy Institute for Drug Research, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, 91120, Israel. Electronic address: adi.schumacher@mail.huji.ac.il.
⁴ Department of Bioengineering, College of Engineering, Temple University, Philadelphia, PA, USA. Electronic address: cmarcink@temple.edu.
⁵ Department of Bioengineering, College of Engineering, Temple University, Philadelphia, PA, USA. Electronic address: pilelkes@temple.edu.
⁶ School of Pharmacy Institute for Drug Research, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, 91120, Israel. Electronic address: philipl@ekmd.huji.ac.il.

PMID: 33589358
DOI: 10.1016/j.cytogfr.2021.01.008

Abstract

Although lung innervation has been described by many studies in humans and rodents, the regulation of the respiratory system induced by neurotrophins is not fully understood. Here, we review current knowledge on the role of neurotrophins and the expression and function of their receptors in neurogenesis, vasculogenesis and during the embryonic development of the respiratory tree and highlight key implications relevant to respiratory diseases.

Keywords: Development; Lung; Neurotrophic factors; Receptors; Respiratory diseases.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Female
Humans
Lung
Lung Diseases*
Nerve Growth Factors
Pregnancy

Substances

Nerve Growth Factors