Limonoids and other triterpenoids from Entandrophragma angolense

Fitoterapia. 2021 Apr:150:104846. doi: 10.1016/j.fitote.2021.104846. Epub 2021 Feb 12.

Abstract

Four new compounds (1-4) were isolated from the stem bark of Entandrophragma angolense along with eleven known structures (5-15). The chemical structures were elucidated on the basis of spectroscopic and HRMS data, and the absolute configuration was established with the aid of electronic circular dichroism. Compound 5 displayed moderate cytotoxicity against MDA-MB-231, OVCAR3, MDA-MB-435, and HT29 cell lines, with IC50 values ranging from 2.0-5.9 μM.

Keywords: Cytotoxicity; Entandrophragma angolense; Limonoid; Meliaceae; Quantitative NMR; Triterpenoid; seco-triterpenoid.

MeSH terms

  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Cell Line, Tumor
  • Humans
  • Limonins / isolation & purification
  • Limonins / pharmacology*
  • Meliaceae / chemistry*
  • Molecular Structure
  • Nigeria
  • Phytochemicals / isolation & purification
  • Phytochemicals / pharmacology
  • Plant Bark / chemistry
  • Plants, Medicinal / chemistry
  • Triterpenes / isolation & purification
  • Triterpenes / pharmacology*

Substances

  • Antineoplastic Agents, Phytogenic
  • Limonins
  • Phytochemicals
  • Triterpenes