P2X7 receptors in the central nervous system

Biochem Pharmacol. 2021 May:187:114472. doi: 10.1016/j.bcp.2021.114472. Epub 2021 Feb 13.

Abstract

For the past three decades, our laboratory has conducted pioneering research to elucidate the complexity of purinergic signaling in the CNS, alone and in collaboration with other groups, inspired by the ground-breaking efforts of Geoffrey Burnstock. This review summarizes our contribution to understand the nucleotide receptor signaling in the CNS with a special focus on the P2X7 receptor.

Keywords: Calcium signaling; Neuroprotection; Neurotransmission; Nucleotide receptor; P2X7 receptor.

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Animals
  • Calcium Signaling / drug effects
  • Calcium Signaling / physiology
  • Central Nervous System / drug effects
  • Central Nervous System / metabolism*
  • Humans
  • Neurodegenerative Diseases / drug therapy
  • Neurodegenerative Diseases / metabolism*
  • Purinergic P2X Receptor Agonists / administration & dosage
  • Purinergic P2X Receptor Antagonists / administration & dosage
  • Receptors, Purinergic P2X7 / metabolism*
  • Signal Transduction / drug effects
  • Signal Transduction / physiology

Substances

  • Purinergic P2X Receptor Agonists
  • Purinergic P2X Receptor Antagonists
  • Receptors, Purinergic P2X7
  • Adenosine Triphosphate