The potentials of probiotics on gluten hydrolysis; a review study

Najmeh Ramedani; Anousheh Sharifan; Fahimeh Sadat Gholam-Mostafaei; Mohammad Rostami-Nejad; Abbas Yadegar; Mohammad Javad Ehsani-Ardakani

The potentials of probiotics on gluten hydrolysis; a review study

Gastroenterol Hepatol Bed Bench. 2020 Winter;13(Suppl1):S1-S7.

Authors

Najmeh Ramedani¹, Anousheh Sharifan¹, Fahimeh Sadat Gholam-Mostafaei², Mohammad Rostami-Nejad², Abbas Yadegar³, Mohammad Javad Ehsani-Ardakani⁴

Affiliations

¹ Department of Food Science and Technology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
² Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
³ Foodborne and Waterborne Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁴ Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

PMID: 33584998
PMCID: PMC7881392

Abstract

Celiac disease (CD) is an autoimmune disorder of the small intestinal mucosa in genetically susceptible subjects consuming gluten. Gluten in wheat, rye and barley is harmful for some individuals and leads to various symptoms. Research has shown that treatment with probiotics in CD patients could improve the symptoms by the gluten hydrolysis. For this purpose, different databases such as Medline, PubMed, Scopus, and Google Scholar were searched using the following keywords: Celiac disease, Wheat flour, Gluten, glutamine, Probiotic, Bifidobacterium, Lactobacillus, Enzymes, Wheat allergy, Immune system, T cells, HLA-DQ2, HLA-DQ8, Gluten-free diet, Proteolysis, α2-gliadin fragment, Gliadin, 33-mer peptide, and Zonulin. The search aimed to retrieve the articles published during 2000-2019. Today, a gluten-free diet (GFD) is the only celiac disease treatment. Biotechnological strategy based on probiotic treatment could degrade gluten. Research has shown that combination of the probiotic enzyme is more effective than single probiotic on gluten hydrolysis. The result of different studies showed that probiotic mixture has the capacity to hydrolyze a considerable concentration of the 33-mer of gliadin completely. The present study was aimed to investigate associations between the capacities of probiotics on gluten hydrolysis.

Keywords: Celiac disease; Gliadin; Gluten-free diet; Probiotics; Wheat.

Publication types

Review