Changes in the Concentration of Purine and Pyridine as a Response to Single Whole-Body Cryostimulation

Wioleta Dudzinska; Anna Lubkowska

doi:10.3389/fphys.2021.634816

Changes in the Concentration of Purine and Pyridine as a Response to Single Whole-Body Cryostimulation

Front Physiol. 2021 Jan 27:12:634816. doi: 10.3389/fphys.2021.634816. eCollection 2021.

Authors

Wioleta Dudzinska^{1

2}, Anna Lubkowska²

Affiliations

¹ Institute of Biology, University of Szczecin, Szczecin, Poland.
² Department of Functional Diagnostics and Physical Medicine, Pomeranian Medical University in Szczecin, Szczecin, Poland.

Abstract

To our knowledge, this is the first study in which we provide evidence that a single whole-body cryostimulation treatment leads to changes associated with erythrocyte energy metabolism. These changes are beneficial from the point of view of cellular bioenergetics, because they are associated with an increase in ATP concentration and erythrocyte energy potential expressed by an increase in the ATP/ADP and ATP/AMP ratios and the value of adenylate energy charge (AEC). In addition, as affected by cryogenic temperatures, there is a decrease in the concentration of purine catabolism products, i.e., inosine and hypoxanthine in the blood.

Keywords: cryostimulation; energy metabolism; erythrocytes; purines; pyridine.