Longitudinal analysis of antibody response following SARS-CoV-2 infection in pregnancy: From the first trimester to delivery

Stefano Cosma; Andrea Roberto Carosso; Silvia Corcione; Jessica Cusato; Fulvio Borella; Miriam Antonucci; Luca Marozio; Alberto Revelli; Mario Preti; Valeria Ghisetti; Giovanni Di Perri; Chiara Benedetto

doi:10.1016/j.jri.2021.103285

Longitudinal analysis of antibody response following SARS-CoV-2 infection in pregnancy: From the first trimester to delivery

J Reprod Immunol. 2021 Apr:144:103285. doi: 10.1016/j.jri.2021.103285. Epub 2021 Feb 2.

Affiliations

¹ Gynecology and Obstetrics 1, Department of Surgical Sciences, City of Health and Science, University of Turin, Turin, Italy.
² Gynecology and Obstetrics 1, Department of Surgical Sciences, City of Health and Science, University of Turin, Turin, Italy. Electronic address: andrea88.carosso@gmail.com.
³ Infectious Diseases, Department of Medical Sciences, University of Turin, Turin, Italy; Tufts University School of Medicine, Boston, MA, USA.
⁴ Laboratory of Clinical Pharmacology and Pharmacogenetics, Amedeo di Savoia Hospital, Department of Medical Sciences, University of Turin, Turin, Italy.
⁵ Laboratory of Microbiology and Virology, Amedeo di Savoia Hospital, ASL 'Città di Torino', Turin, Italy.
⁶ Unit of Infectious Diseases, Amedeo di Savoia Hospital, Department of Medical Sciences, University of Turin, Turin, Italy.

Abstract

We report herein the longest-lasting study of SARS-CoV-2 antibody profile in pregnancy, from first trimester-infection to delivery. Seventeen out of 164 pregnant women tested positive for COVID-19. Throughout pregnancy, the neutralizing antibody titer remained stable, whilst a significant decline in the non-neutralizing antibodies was observed after 16 weeks of gestation. All the newborns of women who developed IgG antibodies showed the presence of the same antibodies in arterial cord blood. Knowledge on the longevity and type of SARS-CoV-2 antibody response may help to guide vaccination strategies in pregnancy.

Keywords: Antibodies; COVID-19 immunology; COVID-19 vaccines; Pregnancy; SARS-CoV-2.

Publication types

Clinical Trial

MeSH terms

Adult
Antibodies, Neutralizing / blood*
Antibodies, Viral / blood*
Antibodies, Viral / immunology
COVID-19 / blood*
COVID-19 / immunology
Female
Humans
Immunoglobulin G / blood*
Immunoglobulin G / immunology
Longitudinal Studies
Pregnancy
Pregnancy Complications, Infectious / blood*
Pregnancy Complications, Infectious / immunology
SARS-CoV-2 / immunology
SARS-CoV-2 / metabolism*

Substances

Antibodies, Neutralizing
Antibodies, Viral
Immunoglobulin G