Abstract
Hepatocyte nuclear factor 1 beta (HNF1 β/B) exists as a homeobox transcription factor having a vital role in the embryonic development of organs mainly liver, kidney and pancreas. Initially described as a gene causing maturity-onset diabetes of the young (MODY), HNF1β expression deregulation and single nucleotide polymorphisms in HNF1β have now been associated with several tumours including endometrial, prostate, ovarian, hepatocellular, renal and colorectal cancers. Its function has been studied either as homodimer or heterodimer with HNF1α. In this review, the role of HNF1B in different cancers will be discussed along with the role of its splice variants, and its emerging role as a potential biomarker in cancer.
Keywords:
cancer; hepatocyte nuclear factor 1beta; splice variants; transcription factor.
© 2021 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Alternative Splicing
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Biomarkers, Tumor / genetics
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Breast Neoplasms / genetics
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DNA Methylation
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Diabetes Mellitus, Type 2 / genetics
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Endometrial Neoplasms / genetics
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Epigenesis, Genetic
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Female
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Hepatocyte Nuclear Factor 1-alpha / genetics
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Hepatocyte Nuclear Factor 1-beta / genetics*
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Hepatocyte Nuclear Factor 4 / genetics
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Humans
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Male
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Multiple Myeloma / genetics
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Neoplasm Proteins / genetics*
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Neoplasms / genetics*
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Organogenesis / genetics
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Ovarian Neoplasms / genetics
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Pancreatic Neoplasms / genetics
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Polymorphism, Single Nucleotide
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Prostatic Neoplasms / genetics
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Protein Isoforms
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Transcription Factors
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Tumor Suppressor Proteins / genetics
Substances
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Biomarkers, Tumor
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HNF4A protein, human
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Hepatocyte Nuclear Factor 1-alpha
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Hepatocyte Nuclear Factor 4
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Neoplasm Proteins
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Protein Isoforms
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Transcription Factors
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Tumor Suppressor Proteins
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Hepatocyte Nuclear Factor 1-beta