TRPC4 ion channel regulations by small-molecular inhibitors and calmodulin

Cell Calcium. 2021 May:95:102361. doi: 10.1016/j.ceca.2021.102361. Epub 2021 Jan 29.

Abstract

TRPC4 ion channel was reported to be regulated by small molecular inhibitors and calmodulin. We discuss these findings in the context of other members of TRPC subfamily modulated by different stimulants.

Keywords: Calmodulin; Small molecular modulator; TRPC4.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Binding Sites / drug effects
  • Binding Sites / physiology
  • Calmodulin / metabolism*
  • Calmodulin / pharmacology
  • Humans
  • Protein Structure, Secondary
  • TRPC Cation Channels / antagonists & inhibitors*
  • TRPC Cation Channels / chemistry
  • TRPC Cation Channels / metabolism*

Substances

  • Calmodulin
  • TRPC Cation Channels
  • TRPC4 ion channel