Abstract
Isobavachalcone (IBC), a naturally occurring chalcone, is mainly isolated from the seeds of Psoralea corylifolia Linn. IBC demonstrates multiple pharmacological activities, including anti-cancer, anti-microbial, anti-inflammatory, antioxidative, neuroprotective, and among others. Several potential targets of IBC, such as AKT, dihydroorotate dehydrogenase (DHODH), have been identified. The pharmacokinetic profiles of IBC have been reported as well. In this review, the pharmacological activities, the underlying mechanisms, the potential targets, and the pharmacokinetic profiles of IBC were summarized. IBC might be a promising lead compound for drug discovery.
Keywords:
Isobavachalcone; Molecular targets; Pharmacokinetic; Pharmacology.
Copyright © 2021 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Anti-Infective Agents / isolation & purification
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Anti-Infective Agents / pharmacology
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Anti-Infective Agents / therapeutic use
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology
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Antineoplastic Agents / therapeutic use
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Antioxidants / isolation & purification
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Antioxidants / pharmacology*
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Antioxidants / therapeutic use
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Apoptosis / drug effects
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Apoptosis / physiology
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Chalcones / isolation & purification
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Chalcones / pharmacology*
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Chalcones / therapeutic use
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Humans
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use
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Psoralea*
Substances
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Anti-Infective Agents
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Antineoplastic Agents
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Antioxidants
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Chalcones
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Plant Extracts
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isobavachalcone