Ruthenium-Catalyzed Cycloadditions to Form Five-, Six-, and Seven-Membered Rings

Chem Rev. 2021 Apr 14;121(7):4045-4083. doi: 10.1021/acs.chemrev.0c01133. Epub 2021 Feb 12.

Abstract

Ruthenium-catalyzed cycloadditions to form five-, six-, and seven-membered rings are summarized, including applications in natural product total synthesis. Content is organized by ring size and reaction type. Coverage is limited to processes that involve formation of at least one C-C bond. Processes that are stoichiometric in ruthenium or exploit ruthenium as a Lewis acid (without intervention of organometallic intermediates), ring formations that occur through dehydrogenative condensation-reduction, σ-bond activation-initiated annulations that do not result in net reduction of bond multiplicity, and photochemically promoted ruthenium-catalyzed cycloadditions are not covered.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Catalysis
  • Cyclization
  • Heterocyclic Compounds / chemical synthesis*
  • Organometallic Compounds / chemistry*
  • Oxidation-Reduction
  • Photochemical Processes
  • Polycyclic Compounds / chemical synthesis*
  • Ruthenium / chemistry*
  • Stereoisomerism

Substances

  • Heterocyclic Compounds
  • Organometallic Compounds
  • Polycyclic Compounds
  • Ruthenium