NG-Circos: next-generation Circos for data visualization and interpretation

Ya Cui; Zhe Cui; Jianfeng Xu; Dapeng Hao; Jiejun Shi; Dan Wang; Hui Xiao; Xiaohong Duan; Runsheng Chen; Wei Li

doi:10.1093/nargab/lqaa069

NG-Circos: next-generation Circos for data visualization and interpretation

NAR Genom Bioinform. 2020 Sep 3;2(3):lqaa069. doi: 10.1093/nargab/lqaa069. eCollection 2020 Sep.

Authors

Ya Cui¹, Zhe Cui², Jianfeng Xu², Dapeng Hao², Jiejun Shi¹, Dan Wang³, Hui Xiao¹, Xiaohong Duan⁴, Runsheng Chen⁵, Wei Li¹

Affiliations

¹ Division of Computational Biomedicine, Department of Biological Chemistry, School of Medicine, University of California, Irvine, CA 92697, USA.
² Division of Biostatistics, Dan L Duncan Cancer Center and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
³ Department of Medicine, Division of Cardiology, University of California, Los Angeles, CA 90095, USA.
⁴ ChosenMed Technology (Beijing) Co. Ltd, Beijing 100176, China.
⁵ CAS Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101,China.

Abstract

Circos plots are widely used to display multi-dimensional next-generation genomic data, but existing implementations of Circos are not interactive with limited support of data types. Here, we developed next-generation Circos (NG-Circos), a flexible JavaScript-based circular genome visualization tool for designing highly interactive Circos plots using 21 functional modules with various data types. To our knowledge, NG-Circos is the most powerful software to construct interactive Circos plots. By supporting diverse data types in a dynamic browser interface, NG-Circos will accelerate the next-generation data visualization and interpretation, thus promoting the reproducible research in biomedical sciences and beyond. NG-Circos is available at https://wlcb.oit.uci.edu/NG-Circos and https://github.com/YaCui/NG-Circos.