A Closer Look at the Cellular and Molecular Components of the Deep/Muscular Fasciae

Int J Mol Sci. 2021 Jan 30;22(3):1411. doi: 10.3390/ijms22031411.

Abstract

The fascia can be defined as a dynamic highly complex connective tissue network composed of different types of cells embedded in the extracellular matrix and nervous fibers: each component plays a specific role in the fascial system changing and responding to stimuli in different ways. This review intends to discuss the various components of the fascia and their specific roles; this will be carried out in the effort to shed light on the mechanisms by which they affect the entire network and all body systems. A clear understanding of fascial anatomy from a microscopic viewpoint can further elucidate its physiological and pathological characteristics and facilitate the identification of appropriate treatment strategies.

Keywords: cells; extracellular matrix; fascia; nerve.

Publication types

  • Review

MeSH terms

  • Animals
  • Collagen / metabolism
  • Extracellular Matrix / physiology
  • Fascia / cytology*
  • Fascia / innervation
  • Fascia / physiology
  • Fibroblasts / physiology
  • Humans
  • Hyaluronic Acid / metabolism
  • Mechanotransduction, Cellular / physiology
  • Muscle, Skeletal / cytology*
  • Muscle, Skeletal / innervation
  • Muscle, Skeletal / physiology
  • Myofibroblasts / physiology
  • Nerve Fibers / physiology
  • Telocytes / physiology
  • Viscosity

Substances

  • Hyaluronic Acid
  • Collagen