Abstract
Post-traumatic stress disorder (PTSD) has a high lifetime prevalence and is one of the more serious challenges in mental health care. Fear-conditioned learning involving the amygdala has been thought to be one of the main causative factors; however, recent studies have reported abnormalities in the thalamus of PTSD patients, which may explain the mechanism of interventions such as eye movement desensitization and reprocessing (EMDR). Therefore, I conducted a miniature literature review on the potential contribution of the thalamus to the pathogenesis of PTSD and the validation of therapeutic approaches. As a result, we noticed the importance of the retinotectal pathway (superior colliculus-pulvinar-amygdala connection) and discussed therapeutic indicators.
Keywords:
EMDR; PTSD; fMRI; morphology; thalamus.
MeSH terms
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Amygdala / diagnostic imaging
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Amygdala / physiopathology*
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Animals
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Conditioning, Psychological / drug effects
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Conditioning, Psychological / physiology
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Connectome / methods
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Diffusion Tensor Imaging
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Disease Models, Animal
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Eye Movement Desensitization Reprocessing / methods
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Fear / physiology
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Fear / psychology
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Humans
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Hyperbaric Oxygenation
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Oxytocin / administration & dosage
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Pulvinar / diagnostic imaging
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Pulvinar / physiopathology*
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Retina / diagnostic imaging
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Retina / physiopathology*
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Stress Disorders, Post-Traumatic / diagnosis
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Stress Disorders, Post-Traumatic / physiopathology*
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Stress Disorders, Post-Traumatic / psychology
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Stress Disorders, Post-Traumatic / therapy
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Superior Colliculi / diagnostic imaging
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Superior Colliculi / physiopathology*
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Treatment Outcome
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Visual Pathways / diagnostic imaging
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Visual Pathways / drug effects
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Visual Pathways / physiopathology