Antihistamine and cationic amphiphilic drugs, old molecules as new tools against the COVID-19?

Med Hypotheses. 2021 Mar:148:110508. doi: 10.1016/j.mehy.2021.110508. Epub 2021 Jan 24.

Abstract

Several studies have reported that certain psychoactive drugs could have a protective effect against SARS-CoV-2. Herein, we propose that antihistamines (anti-H1) and cationic amphiphilic drugs (CAD), specifically, have the capacity to disrupt virus entry and replication. In addition, several of these molecules have limited side effects and as such could be promising prophylactic candidates against SARS-CoV-2 infection.

MeSH terms

  • COVID-19 / virology
  • COVID-19 Drug Treatment*
  • Drug Repositioning
  • Histamine H1 Antagonists / pharmacology*
  • Humans
  • Models, Biological
  • Pandemics
  • SARS-CoV-2* / drug effects
  • SARS-CoV-2* / physiology
  • Surface-Active Agents / pharmacology*
  • Virus Internalization / drug effects
  • Virus Replication / drug effects

Substances

  • Histamine H1 Antagonists
  • Surface-Active Agents