Immunologic goalposts for TB vaccine development

Peter K Um; William R Bishai

doi:10.1016/j.chom.2021.01.011

Immunologic goalposts for TB vaccine development

Cell Host Microbe. 2021 Feb 10;29(2):158-159. doi: 10.1016/j.chom.2021.01.011.

Authors

Peter K Um¹, William R Bishai²

Affiliations

¹ Center for Tuberculosis Research, Johns Hopkins School of Medicine, 1550 Orleans St., Rm 108, Baltimore, MD 21287, USA.
² Center for Tuberculosis Research, Johns Hopkins School of Medicine, 1550 Orleans St., Rm 108, Baltimore, MD 21287, USA. Electronic address: wbishai@jhmi.edu.

Abstract

A limiting factor in identifying effective tuberculosis (TB) vaccines is our incomplete understanding of correlates of protection. In this issue of Cell Host & Microbe, Esaulova et al. reveal cell types associated with TB containment and disease progression in non-human primates, which may provide immunologic goalposts for vaccine design.

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MeSH terms

Animals
Mycobacterium tuberculosis* / immunology
Tuberculosis Vaccines*
Tuberculosis* / prevention & control

Substances

Tuberculosis Vaccines