Tryptophan metabolites get the gut moving

Nicolas Benech; Nathalie Rolhion; Harry Sokol

doi:10.1016/j.chom.2021.01.009

Tryptophan metabolites get the gut moving

Cell Host Microbe. 2021 Feb 10;29(2):145-147. doi: 10.1016/j.chom.2021.01.009.

Authors

Nicolas Benech¹, Nathalie Rolhion¹, Harry Sokol²

Affiliations

¹ Gastroenterology Department, Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine, CRSA, AP-HP, Saint Antoine Hospital, Paris, France; French Group of Faecal Microbiota Transplantation (GFTF), Paris, France; Paris Center for Microbiome Medicine, Fédération Hospitalo-Universitaire, Paris, France.
² Gastroenterology Department, Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine, CRSA, AP-HP, Saint Antoine Hospital, Paris, France; French Group of Faecal Microbiota Transplantation (GFTF), Paris, France; Paris Center for Microbiome Medicine, Fédération Hospitalo-Universitaire, Paris, France; INRA, UMR1319 Micalis & AgroParisTech, Jouy en Josas, France. Electronic address: harry.sokol@aphp.fr.

PMID: 33571438
DOI: 10.1016/j.chom.2021.01.009

Abstract

How gut microbes can regulate the enteric nervous system and gut-brain communications is a field of intense research. In this issue of Cell Host & Microbe, Ye et al. demonstrate that bacteria can control intestinal motility and vagal neuronal activation via tryptophan catabolites through the receptor TrpA1 of enteroendocrine cells.

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MeSH terms

Bacteria
Enteric Nervous System*
Enteroendocrine Cells
Gastrointestinal Microbiome*
Tryptophan

Substances

Tryptophan