Pathophysiology and pathology of acute cholecystitis: A secondary publication of the Japanese version from 1992

J Hepatobiliary Pancreat Sci. 2022 Feb;29(2):212-216. doi: 10.1002/jhbp.912. Epub 2021 Mar 27.

Abstract

Acute cholecystitis is a progressive inflammation of the gallbladder usually caused by gallstones obstructing the cystic duct. Congestion and edema are evident symptoms during the first 2-4 days, also known as the phase of edematous cholecystitis. Necrotizing cholecystitis, a phase characterized by bleeding and necrosis, is seen at 3-5 days. From 7-10 days, the disease progresses to its purulent phase, also known as suppurative cholecystitis. If the disease is still left untreated at this point, it progresses to subacute cholecystitis and it eventually becomes chronic cholecystitis. Possible complications that affect the management of cholecystitis include perforation of the gallbladder (bile peritonitis) during the hemorrhagic and necrosis phase, and peri-gallbladder abscess and internal biliary fistula during the purulent phase.

Keywords: acute cholecystitis; gallbladder; pathological findings.

Publication types

  • Review

MeSH terms

  • Cholecystitis* / surgery
  • Cholecystitis, Acute* / diagnosis
  • Cholecystitis, Acute* / surgery
  • Gallbladder
  • Gallstones*
  • Humans
  • Japan