Prognostic nomogram for surgery of lung cancer in HIV-infected patients

Lin Wang; Liwei Wu; Jianjian Liu; Laiyi Wan; Hui Chen; Yijun Zhu; Jun Wang; Hongwei Li; Lei Shi; Leilei Li; Yanzheng Song

doi:10.21037/jtd-20-2268

Prognostic nomogram for surgery of lung cancer in HIV-infected patients

J Thorac Dis. 2021 Jan;13(1):76-81. doi: 10.21037/jtd-20-2268.

Authors

Lin Wang¹, Liwei Wu¹, Jianjian Liu², Laiyi Wan¹, Hui Chen¹, Yijun Zhu¹, Jun Wang¹, Hongwei Li¹, Lei Shi¹, Leilei Li¹, Yanzheng Song¹

Affiliations

¹ Department of Thoracic Surgery, Shanghai Public Health Clinical Center, Fudan University Shanghai, China.
² Department of Ultrasonic Room, Shanghai Public Health Clinical Center, Shanghai, China.

Abstract

Background: This study aimed to establish an effective prognostic nomogram for surgery of lung cancer in HIV-infected patients.

Methods: The nomogram is based on a retrospective study of 51 patients who underwent lung cancer surgery at the Shanghai Public Health Clinical Center from July 2012 to November 2019. The predictive accuracy and discriminative ability of the nomogram were determined by concordance index (C-index) and calibration curve analysis. Internal validity was assessed using bootstrapping validation.

Results: Predictors contained in the prognostic nomogram included age, CD4+ cell count, surgery method, and pathological stage. The model displayed good discrimination with a C-index of 0.755 (95% CI: 0.715-0.795) and good calibration. A high C-index value of 0.844 was reached after internal validation.

Conclusions: The proposed nomogram may result in more-accurate prognostic predictions for surgery of lung cancer in HIV-infected patients.

Keywords: Nomogram; human immunodeficiency virus; non-small cell lung cancer (NSCLC); prognosis.