Elevated plasma Sirtuin2 level predicts heart failure after acute myocardial infarction

Meili Zheng; Xiangpeng Du; Lei Zhao; Hao Sun; Mulei Chen; Xinchun Yang

doi:10.21037/jtd-20-2234

Elevated plasma Sirtuin2 level predicts heart failure after acute myocardial infarction

J Thorac Dis. 2021 Jan;13(1):50-59. doi: 10.21037/jtd-20-2234.

Authors

Meili Zheng^{1

2}, Xiangpeng Du³, Lei Zhao^{1

2}, Hao Sun¹, Mulei Chen¹, Xinchun Yang^{1

2}

Affiliations

¹ Heart Center, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
² Beijing Key Laboratory of Hypertension Research, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
³ Department of Cardiology, Weihaiwei People's Hospital, Weihai, China.

Abstract

Background: There is currently no evidence regarding the role of plasma Sirtuin2 (SIRT2) level in acute myocardial infarction (AMI) yet. This study assessed the role of plasma SIRT2 in AMI, and investigated the association of plasma SIRT2 level with major adverse cardiovascular events (MACE) and heart failure after AMI.

Methods: This is a prospective observational study. A total of 129 AMI patients (mean age: 62.2±12.7 years old, male/female: 96/33) were included. Cox proportional hazards regression models were used to estimate the association of different SIRT2 levels with MACE and heart failure after AMI.

Results: According to the 75th percentile value of plasma SIRT2 level, we divided all the AMI patients into two groups: high-level group (plasma SIRT2 level ≥109.0 pg/mL) and low-level group (plasma SIRT2 level <109.0 pg/mL). Compared with the low-level group, the high-level group had higher percentage of Killip class ≥3 (P<0.001), left ventricular ejection fraction (LVEF) <50% (P=0.007) or even <40% (P=0.012), use of breathing machine(P=0.003), and higher plasma brain natriuretic peptide (BNP) level (P=0.006). Multivariate Cox regression analysis showed that there were higher risks of MACE [hazard ratio (HR) 11.20, 95% confidence interval (CI): 3.18-39.52, P<0.001)] and heart failure (HR 27.10, 95% CI: 4.65-157.83, P<0.001) in the high-level group.

Conclusions: The present study suggested that plasma SIRT2 level is a promising biomarker to predict heart failure and MACE after AMI.

Keywords: ST-segment elevation myocardial infarction (STEMI); Sirtuin2 (SIRT2); acute myocardial infarction (AMI); non-ST-segment elevation myocardial infarction (NSTEMI).