Characterization of Artificial Pneumothorax-Unrelated Pyothorax-Associated Lymphoma

Guang-Liang Chen; Zu-Guang Xia; Jia Jin; Bao-Hua Yu; Junning Cao

doi:10.1155/2021/3869438

Characterization of Artificial Pneumothorax-Unrelated Pyothorax-Associated Lymphoma

J Oncol. 2021 Jan 25:2021:3869438. doi: 10.1155/2021/3869438. eCollection 2021.

Authors

Guang-Liang Chen^{1

2}, Zu-Guang Xia^{1

2}, Jia Jin^{1

2}, Bao-Hua Yu^{2

3}, Junning Cao^{1

2}

Affiliations

¹ Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
² Department of Oncology, Shanghai Medical College of Fudan University, Shanghai 200032, China.
³ Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.

Abstract

Pyothorax-associated lymphoma (PAL) is a rare disease developing from a long-term pleural cavity inflammation. Most reported PAL cases have a history of artificial pneumothorax. However, the clinical features of artificial pneumothorax-unrelated PAL remain largely unknown. Here, we reported two PAL cases diagnosed from our center in the past ten years. One case developed from asymptomatic pyothorax after pneumonectomy with a latency of 28 years, while the other case showed a relatively short latency of one year. Then we reviewed the literature of artificial pneumothorax-unrelated PAL by searching PubMed and Google Scholar from 2007. In total, nine artificial pneumothorax-unrelated PAL cases were found, predominantly in old male with median age of 76 years (ranging from 51 to 88). Most cases were diagnosed with diffuse large B-cell lymphoma (DLBCL) (n = 8, 88.9%) and had evidence of Epstein-Barr virus (EBV) infection (n = 6, 66.7%) or tuberculous pleurisy (n = 5, 55.6%). Notably, four cases (44.4%) had short intervals (no more than two years) between pleuritis and PAL. Regarding the overall survival, one-third cases survived more than 5 years after the diagnosis of PAL. In conclusion, the features of artificial pneumothorax-unrelated PAL are comparable with the classic type of PAL, except for some patients with short duration of pleuritis, and need to be identified. Treatment guideline of DLBCL is recommended for the management of PAL.