Severe and Irreversible Pancytopenia Associated With SARS-CoV-2 Bone Marrow Infection in a Patient With Waldenstrom Macroglobulinemia

Mélanie Velier; Stéphane Priet; Romain Appay; Thérèse Atieh; Hubert Lepidi; Gilles Kaplanski; Pierre André Jarrot; Marie Koubi; Régis Costello; Françoise Dignat-George; Xavier de Lamballerie; Antoine Tichadou; Robin Arcani; Anne Laure Couderc; Julian Touati; Arthur Varoquaux; Yaël Berda-Haddad; Geoffroy Venton

doi:10.1016/j.clml.2021.01.005

Severe and Irreversible Pancytopenia Associated With SARS-CoV-2 Bone Marrow Infection in a Patient With Waldenstrom Macroglobulinemia

Clin Lymphoma Myeloma Leuk. 2021 Jun;21(6):e503-e505. doi: 10.1016/j.clml.2021.01.005. Epub 2021 Jan 13.

Authors

Mélanie Velier¹, Stéphane Priet², Romain Appay³, Thérèse Atieh², Hubert Lepidi⁴, Gilles Kaplanski⁵, Pierre André Jarrot⁵, Marie Koubi⁶, Régis Costello⁷, Françoise Dignat-George⁸, Xavier de Lamballerie², Antoine Tichadou⁹, Robin Arcani¹⁰, Anne Laure Couderc¹¹, Julian Touati¹², Arthur Varoquaux¹², Yaël Berda-Haddad¹³, Geoffroy Venton⁹

Affiliations

¹ Laboratory of Hematology and Vascular biology, Conception University Hospital, Marseille, France; Center for Cardiovascular and Nutrition Research (C2VN), INRA 1260, INSERM 1263, Aix-Marseille University, Marseille, France. Electronic address: melanie.velier@ap-hm.fr.
² Unité des Virus Émergents (UVE), IRD 190, Inserm 1207, Aix-Marseille University, Marseille, France.
³ Pathology and Neuropathology Department, La Timone University Hospital, Marseille, France; CNRS, INP, Inst Neurophysiopathol, Aix-Marseille University, Marseille, France.
⁴ Pathology and Neuropathology Department, La Timone University Hospital, Marseille, France.
⁵ Center for Cardiovascular and Nutrition Research (C2VN), INRA 1260, INSERM 1263, Aix-Marseille University, Marseille, France; Internal Medical and Clinical Immunology, Conception University Hospital, Marseille, France.
⁶ Internal Medical and Clinical Immunology, Conception University Hospital, Marseille, France.
⁷ Hematology and Cellular Therapy Department, Conception University Hospital, Marseille, France; TAGC, INSERM, UMR1090, Aix-Marseille University, Marseille, France.
⁸ Laboratory of Hematology and Vascular biology, Conception University Hospital, Marseille, France; Center for Cardiovascular and Nutrition Research (C2VN), INRA 1260, INSERM 1263, Aix-Marseille University, Marseille, France.
⁹ Hematology and Cellular Therapy Department, Conception University Hospital, Marseille, France; TAGC, INSERM, UMR1090, Aix-Marseille University, Marseille, France; SMARTc Unit, Pharmacokinetics Laboratory, UMR_911 CRO2 Aix-Marseille University, Marseille, France.
¹⁰ Center for Cardiovascular and Nutrition Research (C2VN), INRA 1260, INSERM 1263, Aix-Marseille University, Marseille, France; Internal Medicine, Geriatrics and Therapeutics Department and Coordination Unit for Geriatric Oncology (UCOG), La Timone University Hospital, Marseille, France.
¹¹ Internal Medicine, Geriatrics and Therapeutics Department and Coordination Unit for Geriatric Oncology (UCOG), La Timone University Hospital, Marseille, France; CNRS, EFS, ADES, Aix-Marseille University, Marseille, France.
¹² Department of Medical Imaging, Conception University Hospital, Marseille, France; Center for Magnetic Resonance in Biology and Medicine, UMR 7339, La Timone University Hospital, Aix-Marseille University, Marseille, France.
¹³ Laboratory of Hematology and Vascular biology, Conception University Hospital, Marseille, France.

No abstract available

Keywords: Aplasia; COVID-19; Indirect immunofluorescence; Lymphoproliferative disorder; Monoclonal immunoglobulin.

Publication types

Case Reports

MeSH terms

Bone Marrow / pathology
Bone Marrow / virology*
COVID-19 / complications*
COVID-19 / pathology
COVID-19 / virology
Fatal Outcome
Female
Humans
Middle Aged
Pancytopenia / etiology*
Pancytopenia / pathology
Pancytopenia / virology
SARS-CoV-2 / isolation & purification
SARS-CoV-2 / pathogenicity*
Waldenstrom Macroglobulinemia / complications*
Waldenstrom Macroglobulinemia / pathology
Waldenstrom Macroglobulinemia / virology