Abstract
Despite some success, many patients do not benefit from immunotherapy. New strategies to improve clinical efficacy include identification of novel immune-checkpoint (IC) targets or a combination of immunotherapy with antiangiogenic treatments. Here, we propose the therapeutic use of IC, HLA-G/LILRB, and explore its enhanced synergistic antitumor activity when combined with antiangiogenic therapies.
Keywords:
HLA-G; LILRB1/2; cancer immunotherapy; immune checkpoints; vascular endothelial growth factor; vascular targeting.
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.
MeSH terms
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Angiogenesis Inhibitors / pharmacology
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Angiogenesis Inhibitors / therapeutic use
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Antigens, CD / metabolism*
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Antineoplastic Combined Chemotherapy Protocols / pharmacology*
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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CD8-Positive T-Lymphocytes / drug effects
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CD8-Positive T-Lymphocytes / immunology
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CD8-Positive T-Lymphocytes / metabolism
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Drug Synergism
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HLA-G Antigens / metabolism*
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Humans
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Immune Checkpoint Inhibitors / pharmacology
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Immune Checkpoint Inhibitors / therapeutic use
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Immune Checkpoint Proteins / metabolism
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Immunotherapy, Adoptive / methods*
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Leukocyte Immunoglobulin-like Receptor B1 / antagonists & inhibitors
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Leukocyte Immunoglobulin-like Receptor B1 / metabolism*
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Lymphocytes, Tumor-Infiltrating / drug effects
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Lymphocytes, Tumor-Infiltrating / immunology
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Lymphocytes, Tumor-Infiltrating / metabolism
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Membrane Glycoproteins / antagonists & inhibitors
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Membrane Glycoproteins / metabolism*
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Neoplasms / immunology
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Neoplasms / therapy*
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Receptors, Chimeric Antigen / immunology
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Receptors, Immunologic / antagonists & inhibitors
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Receptors, Immunologic / metabolism*
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Tumor Escape
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Tumor Microenvironment / drug effects
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Tumor Microenvironment / immunology
Substances
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Angiogenesis Inhibitors
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Antigens, CD
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HLA-G Antigens
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Immune Checkpoint Inhibitors
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Immune Checkpoint Proteins
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LILRB1 protein, human
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LILRB2 protein, human
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Leukocyte Immunoglobulin-like Receptor B1
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Membrane Glycoproteins
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Receptors, Chimeric Antigen
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Receptors, Immunologic