Objective: To summarize current knowledge about the composition and function of the vernix caseoza with respect to the prenatal and postnatal period.
Design: Summary article.
Setting: Department of Obstetrics and Gynecology, University Hospital Hradec Kralove.
Conclusion: According to current knowledge about composition, vernix caseoza consists of desquamate cells from outer layers of epidermidis with proteolipid material. The formation of vernix caseoza is related to the formation of the fetal skin. The lipid content protects a fetus from maceration with amniotic fluid. Vernix caseoza further enhance the process of adaptation during the transition of a newborn from intrauterine to postnatal life. During delivery, vernix caseoza serves mainly as lubricant function. In a postpartum period, verxic caseoza may have moisturizing, antiinflammatory, antioxidative and healing function.
Keywords: biofilm; corneocyte; fetus; new-born child; newborn; vernix caseoza.