Stop the Divide and Build Coronary Arteries

G Zarkada; A Eichmann

doi:10.1016/j.devcel.2021.01.008

Stop the Divide and Build Coronary Arteries

Dev Cell. 2021 Feb 8;56(3):255-256. doi: 10.1016/j.devcel.2021.01.008.

Authors

G Zarkada¹, A Eichmann²

Affiliations

¹ Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
² Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA; Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA; Université de Paris, PARCC, INSERM, Paris, France. Electronic address: anne.eichmann@yale.edu.

PMID: 33561420
DOI: 10.1016/j.devcel.2021.01.008

Abstract

Understanding how arteries develop is critical to design repair strategies for coronary artery disease and treatment of arteriovenous malformations. Luo et al. report in Nature that NOTCH drives coronary artery formation by suppressing MYC, a transcription factor involved in cell cycle progression and cell metabolism.

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MeSH terms

Coronary Vessels*
Humans