Ergothioneine, recent developments

Irwin K Cheah; Barry Halliwell

doi:10.1016/j.redox.2021.101868

Ergothioneine, recent developments

Redox Biol. 2021 Jun:42:101868. doi: 10.1016/j.redox.2021.101868. Epub 2021 Jan 26.

Authors

Irwin K Cheah¹, Barry Halliwell²

Affiliations

¹ Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 117596, Singapore; Life Science Institute, Neurobiology Programme, Centre for Life Sciences, National University of Singapore, 117456, Singapore.
² Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 117596, Singapore; Life Science Institute, Neurobiology Programme, Centre for Life Sciences, National University of Singapore, 117456, Singapore. Electronic address: bchbh@nus.edu.sg.

Abstract

There has been a recent surge of interest in the unique low molecular weight dietary thiol/thione, ergothioneine. This compound can accumulate at high levels in the body from diet and may play important physiological roles in human health and development, and possibly in prevention and treatment of disease. Blood levels of ergothioneine decline with age and onset of various diseases. Here we highlight recent advances in our knowledge of ergothioneine.

Keywords: Antioxidant; Ergothioneine; Mushroom; OCTN1; Thiol/thione.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antioxidants
Diet
Ergothioneine*
Humans

Substances

Antioxidants
Ergothioneine