Focus on the Gut-Kidney Axis in Health and Disease

Elisavet Stavropoulou; Konstantia Kantartzi; Christina Tsigalou; Theoharis Konstantinidis; Gioulia Romanidou; Chrysa Voidarou; Eugenia Bezirtzoglou

doi:10.3389/fmed.2020.620102

Focus on the Gut-Kidney Axis in Health and Disease

Front Med (Lausanne). 2021 Jan 21:7:620102. doi: 10.3389/fmed.2020.620102. eCollection 2020.

Authors

Elisavet Stavropoulou^{1

2}, Konstantia Kantartzi³, Christina Tsigalou³, Theoharis Konstantinidis³, Gioulia Romanidou⁴, Chrysa Voidarou⁵, Eugenia Bezirtzoglou³

Affiliations

¹ Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.
² Department of Infectious Diseases, Central Institute, Valais Hospital, Sion, Switzerland.
³ Department of Medicine, Democritus University of Thrace, Alexandroupolis, Greece.
⁴ Hospital "Sismanoglio", Komotini, Greece.
⁵ Department of Public Health P.U., Arta, Greece.

Abstract

The recent new developments in technology with culture-independent techniques including genome sequencing methodologies shed light on the identification of microbiota bacterial species and their role in health and disease. Microbiome is actually reported as an important predictive tool for evaluating characteristic shifts in case of disease. Our present review states the development of different renal diseases and pathologies linked to the intestinal dysbiosis, which impacts on host homeostasis. The gastrointestinal-kidney dialogue provides intriguing features in the pathogenesis of several renal diseases. Without any doubt, investigation of this interconnection consists one of the most cutting-edge areas of research with potential implications on our health.

Keywords: disease; gut; gut–kidney axis; health; kidney; microbiome.

Publication types

Review