Case Report: A Case With Philadelphia Chromosome Positive T-Cell Lymphoblastic Lymphoma and a Review of Literature

Xuewei Li; Nana Ping; Yong Wang; Xiaoyu Xu; Lijuan Gao; Zhao Zeng; Ling Zhang; Zhibo Zhang; Yiyu Xie; Changgeng Ruan; Depei Wu; Zhengming Jin; Suning Chen

doi:10.3389/fonc.2020.584149

Case Report: A Case With Philadelphia Chromosome Positive T-Cell Lymphoblastic Lymphoma and a Review of Literature

Front Oncol. 2021 Jan 20:10:584149. doi: 10.3389/fonc.2020.584149. eCollection 2020.

Authors

Xuewei Li^{1

2}, Nana Ping^{1

3}, Yong Wang^{1

2}, Xiaoyu Xu^{1

2}, Lijuan Gao^{1

2}, Zhao Zeng¹, Ling Zhang¹, Zhibo Zhang¹, Yiyu Xie⁴, Changgeng Ruan^{1

2

3}, Depei Wu^{1

2

3}, Zhengming Jin^{1

3}, Suning Chen^{1

2

3}

Affiliations

¹ Department of Hematology, First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases, Suzhou, China.
² Department of Thrombosis and Hemostasis, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Suzhou, China.
³ Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China.
⁴ Department of Internal Medicine, Yale New Haven Health/Bridgeport Hospital, Bridgeport, CT, United States.

Abstract

Philadelphia chromosome positive (Ph⁺) in T-lineage acute lymphoproliferative tumors is a rare event in both children and adults. In particular, it has not been reported in T-cell lymphoblastic lymphoma(T-LBL) yet. Here, we describe a patient with Ph⁺ T-LBL for both cytogenetic abnormality and BCR-ABL1 fusion transcript. Moreover, we review the published cases of Ph⁺ T-cell acute lymphoblastic leukemia (T-ALL) in the literature and summarize their clinical characteristics, management, and prognosis.

Keywords: Philadelphia chromosome; T-cell lymphoblastic lymphoma; clinical characteristics; managements; prognosis.

Publication types

Case Reports