Risk Factors of New Cerebral Infarctions After Endovascular Treatment for Basilar Artery Stenosis Based on High-Resolution Magnetic Resonance Imaging

Jichang Luo; Long Li; Tao Wang; Kun Yang; Yao Feng; Renjie Yang; Yan Ma; Peng Gao; Bin Yang; Liqun Jiao

doi:10.3389/fneur.2020.620031

Risk Factors of New Cerebral Infarctions After Endovascular Treatment for Basilar Artery Stenosis Based on High-Resolution Magnetic Resonance Imaging

Front Neurol. 2021 Jan 20:11:620031. doi: 10.3389/fneur.2020.620031. eCollection 2020.

Authors

Jichang Luo^{1

2}, Long Li^{1

2}, Tao Wang^{1

2}, Kun Yang³, Yao Feng^{1

2}, Renjie Yang^{1

2}, Yan Ma^{1

2}, Peng Gao^{1

2

4}, Bin Yang^{1

2}, Liqun Jiao^{1

2

4}

Affiliations

¹ China International Neuroscience Institute (China-INI), Beijing, China.
² Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
³ Department of Evidence-Based Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.
⁴ Department of Interventional Neuroradiology, Xuanwu Hospital, Capital Medical University, Beijing, China.

Abstract

Objective: The current study aims to analyze the risk factors of new cerebral infarctions in the distribution of basilar artery (BA) detected by diffusion-weighted imaging (DWI) after endovascular treatment in patients with severe BA stenosis. Methods: Data was collected from the electronic medical records of patients with severely atherosclerotic basilar artery stenosis (≥70%) who underwent endovascular treatment. The plaque characteristics, including the plaque distribution, plaque burden, plaque enhancement index, remodeling ratio, and stenosis degree, were evaluated qualitatively and quantitatively using high-resolution magnetic resonance imaging (HR-MRI) and digital subtraction angiography (DSA). The characteristics of the procedure, such as the type of treatment, balloon diameter, balloon length, stent diameter, and stent length, were analyzed. Results: A total of 107 patients with severe basilar artery stenosis (≥70%) who underwent endovascular treatment were enrolled. The study participants included 77 men and 30 women, with an average age of 61.6 ± 8.1 years. The rate of postoperative new cerebral infarctions was 55.1% (59/107), of which 74.6% (44/59) were caused by artery-to-artery embolism, 6.8% (4/59) due to perforator occlusion, and 18.6% (11/59) were caused by a mixed mechanism. Twelve of 59 patients had ischemic events, with nine cases of stroke and three cases of transient ischemic attacks (TIA). The plaque burden in the DWI-positive group was significantly larger than that in the DWI-negative group (3.7% vs. -8.5%, p = 0.016). Positive remodeling was more common in the DWI-positive group than in the DWI-negative group (35.6% vs. 16.7%, p = 0.028). Smoking was inversely correlated with the rate of new cerebral infarctions (odds ratio, 0.394; 95% confidence interval, 0.167-0.926; p = 0.033). Conclusion: The plaque characteristics are not associated with new cerebral infarctions in the distribution of BA, although a large plaque burden and positive remodeling are more likely to appear in patients with new cerebral infarctions after BA stenting, which warrants further studies with a larger sample size. As for smoking, the inverse correlation with new cerebral infarctions in the BA territory needs large-scale prospective randomized controlled trials to verify.

Keywords: basilar artery stenosis; high-resolution magnetic resonance imaging; new cerebral infarctions; plaque burden; remodeling index; smoking.