New malonylginsenosides from the fresh fruits of Panax notoginseng

Abstract

Four new malonylginsenosides, malonylnotoginsenoside Fe (1), malonylnotoginsenoside Ra₁ (2), malonylgypenoside LXXV (3), and malonylginsenoside Mc (4), together with two known analogues, malonylfloralginsenoside Rc₁ (5) and malonylginsenoside Rc (6), were isolated from the fresh fruits of Panax notoginseng. Their structures were determined by MS and NMR experiments. The anti-proliferative activities of the malonylginsenosides (1-6) against SH-SY5Y human neuroblastoma cell line were evaluated using the MTT assay.

Keywords: Cytotoxicity; Fruits; Malonylginsenosides; NMR; Panax notoginseng.