Prepregnancy antiinflammatory diet in pregnant women with endometriosis: The Japan Environment and Children's Study

Abstract

Objectives: Increased risk of preterm birth (PTB) in women with endometriosis is considered to be associated with chronic inflammatory conditions. Accordingly, we hypothesized that a prepregnancy antiinflammatory diet is a potential form of preconception care for preventing PTB in women with endometriosis and conducted this study to investigate the correlation of a prepregnancy antiinflammatory diet with obstetric outcomes in this patient population.

Methods: We used singleton pregnancy data from the Japan Environment and Children's Study involving live births from 2011 to 2014. Individual meal patterns before pregnancy, derived through food frequency questionnaires, were used to calculate the Dietary Inflammatory Index. Participants were categorized according to Dietary Inflammatory Index quintiles (Q1 and Q5 were the most proinflammatory and antiinflammatory groups, respectively), and a multiple logistic regression model was used to estimate the effect of the antiinflammatory diet on PTB before 37 or 34 wk and on low birth weight (LBW) <2500 or 1500 g.

Results: In women who did not undergo assisted reproduction, significantly reduced risk was found in the Q5 group for both PTB at <34 wk significantly decreased (adjusted odds ratio, 0.25; 95% confidence interval, 0.07-0.83) and low birth weight <1500 g (adjusted odds ratio, 0.07; 95% confidence interval, 0.01-0.60).

Conclusions: This study suggests a distinct effect of an antiinflammatory diet on more severe obstetric outcomes, specifically PTB before 34 wk and low birth weight <1500 g, for women with endometriosis. Preconception lifestyle can improve perinatal mortality and morbidity among these women.

Keywords: Birth cohort study; Dietary Inflammatory Index; Low-birth-weight infant; Preconception care; Preterm birth.