Sodium ion channels as potential therapeutic targets for cancer metastasis

Drug Discov Today. 2021 May;26(5):1136-1147. doi: 10.1016/j.drudis.2021.01.026. Epub 2021 Feb 3.

Authors

Jesse Horne¹, Shomit Mansur², Yuping Bao³

Affiliations

¹ Department of Chemical and Biomolecular Engineering, The University of Illinois at Urbana-Champaign, 114 Roger Adams Laboratory, MC 712 600 South Mathews Avenue, Urbana, IL 61801, USA.
² Chemical and Biological Engineering, Box 370203, The University of Alabama, Tuscaloosa, AL 35487, USA.
³ Chemical and Biological Engineering, Box 370203, The University of Alabama, Tuscaloosa, AL 35487, USA. Electronic address: ybao@eng.ua.edu.

PMID: 33545383
DOI: 10.1016/j.drudis.2021.01.026

Abstract

Is it possible to develop drugs for the treatment of a specific type of metastatic cancer by targeting sodium ion channels?

Copyright © 2021 Elsevier Ltd. All rights reserved.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Animals
Antineoplastic Agents / pharmacology
Binding Sites
Drug Design
Drug Development / methods
Humans
Molecular Targeted Therapy*
Neoplasm Metastasis
Neoplasms / pathology*
Neoplasms / therapy
Voltage-Gated Sodium Channels / chemistry
Voltage-Gated Sodium Channels / metabolism*

Substances

Antineoplastic Agents
Voltage-Gated Sodium Channels