Membrane Tension Locks In Pluripotency

Jonathon M Muncie; Valerie M Weaver

doi:10.1016/j.stem.2021.01.008

Membrane Tension Locks In Pluripotency

Cell Stem Cell. 2021 Feb 4;28(2):175-176. doi: 10.1016/j.stem.2021.01.008.

Authors

Jonathon M Muncie¹, Valerie M Weaver²

Affiliations

¹ Gladstone Institutes, San Francisco, CA 94158, USA.
² Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; UCSF Comprehensive Cancer Center, Helen Diller Family Cancer Research Center, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Anatomy, Department of Bioengineering and Therapeutic Sciences, Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: valerie.weaver@ucsf.edu.

PMID: 33545073
DOI: 10.1016/j.stem.2021.01.008

Abstract

In this issue of Cell Stem Cell, De Belly et al. (2021) and Bergert et al. (2021) reveal that membrane tension regulates the pluripotent state via endocytosis-mediated ERK signaling. These findings advance our understanding of naive pluripotency and highlight how cell mechanics are intertwined with molecular signaling to drive cell fate decisions.

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MeSH terms

Cell Differentiation
Embryonic Stem Cells*
Endocytosis
Signal Transduction*