Bacterial Growth Mindset: Structural Plasticity in Defense Systems

Christina R Bourne

doi:10.1016/j.str.2021.01.007

Bacterial Growth Mindset: Structural Plasticity in Defense Systems

Structure. 2021 Feb 4;29(2):97-98. doi: 10.1016/j.str.2021.01.007.

Author

Christina R Bourne¹

Affiliation

¹ University of Oklahoma, Department of Chemistry and Biochemistry, Norman, OK 73019, USA. Electronic address: cbourne@ou.edu.

PMID: 33545061
DOI: 10.1016/j.str.2021.01.007

Abstract

In this issue of Structure, Bertelsen et al. determine the three-dimensional structures of the Haemophilus influenzae VapD toxin, a Cas-2 homolog, with and without its cognate neutralizing antitoxin, VapX, that together comprise a toxin-antitoxin system. These reveal a unique stoichiometry, with two VapD toxins neutralized simultaneously by one VapX antitoxin.

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MeSH terms

Antitoxins*
Bacterial Proteins
Bacterial Toxins*
Haemophilus influenzae
Toxin-Antitoxin Systems*

Substances

Antitoxins
Bacterial Proteins
Bacterial Toxins