Another battle won in the phage-host arms race: Pseudomonas phage blocks quorum sensing regulator LasR

Julia C van Kessel; Sampriti Mukherjee

doi:10.1016/j.molcel.2021.01.007

Another battle won in the phage-host arms race: Pseudomonas phage blocks quorum sensing regulator LasR

Mol Cell. 2021 Feb 4;81(3):420-422. doi: 10.1016/j.molcel.2021.01.007.

Authors

Julia C van Kessel¹, Sampriti Mukherjee²

Affiliations

¹ Department of Biology, Indiana University, Bloomington, Indiana 47405, USA. Electronic address: jcvk@indiana.edu.
² Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637, USA.

PMID: 33545057
DOI: 10.1016/j.molcel.2021.01.007

Abstract

Shah et al. (2021) uncover phage-encoded protein Aqs1 that tactically blocks Pseudomonas aeruginosa quorum-sensing receptor LasR immediately upon infection to counteract the host's quorum-sensing program, a defense strategy that is likely conserved in other phages.

Publication types

Comment

MeSH terms

Bacterial Proteins / genetics
Bacteriophages* / genetics
Pseudomonas Phages* / genetics
Pseudomonas aeruginosa / genetics
Quorum Sensing
Trans-Activators

Substances

Bacterial Proteins
Trans-Activators

Grants and funding

R35 GM124698/GM/NIGMS NIH HHS/United States