Collector type and pulp pH play an important role in the lead-zinc ore flotation process. In the current study, the effect of pulp pH and the collector type parameters on the galena and sphalerite flotation from a complex lead-zinc-iron ore was investigated. The ethyl xanthate and Aero 3418 collectors were used for lead flotation and Aero 3477 and amyl xanthate for zinc flotation. It was found that maximum lead grade could be achieved by using Aero 3418 as collector at pH 8. Also, iron and zinc recoveries and grades were increased in the lead concentrate at lower pH which caused zinc recovery reduction in the zinc concentrate and decrease the lead grade concentrate. Furthermore, the results showed that the maximum zinc grade and recovery of 42.9% and 76.7% were achieved at pH 6 in the presence of Aero 3477 as collector. For both collectors at pH 5, Zinc recovery was increased around 2-3%; however, the iron recovery was also increased at this pH which reduced the zinc concentrate quality. Finally, pH 8 and pH 6 were selected as optimum pH values for lead and zinc flotation circuits, respectively.