Contemporary Pharmacotherapeutic Approach in Pulmonary Arterial Hypertension

Jalil Ahari; Akshay Bhatnagar; Anna Johnson; Mardi Gomberg-Maitland

doi:10.1016/j.ccm.2020.10.002

Contemporary Pharmacotherapeutic Approach in Pulmonary Arterial Hypertension

Clin Chest Med. 2021 Mar;42(1):125-131. doi: 10.1016/j.ccm.2020.10.002. Epub 2021 Jan 8.

Authors

Jalil Ahari¹, Akshay Bhatnagar¹, Anna Johnson¹, Mardi Gomberg-Maitland²

Affiliations

¹ George Washington University School of Medicine and Health Sciences, 2150 Pennsylvania Avenue 4th Floor, Washington, DC 20037, USA.
² George Washington University School of Medicine and Health Sciences, 2150 Pennsylvania Avenue 4th Floor, Washington, DC 20037, USA. Electronic address: mgomberg@mfa.gwu.edu.

PMID: 33541606
DOI: 10.1016/j.ccm.2020.10.002

Abstract

Since the 1973 World Symposium on Pulmonary Hypertension, advancements in the understanding of pathophysiology and pathobiology have led to a myriad of pharmacotherapies for the disease. This article journeys through the development of therapeutic approaches for pulmonary arterial hypertension.

Keywords: Clinical trials; Endothelial antagonist; Guanylate cyclase stimulator; Pharmacologic treatment approach; Phosphodiesterase inhibitor; Prostacyclin; Prostanoid.

Publication types

Review

MeSH terms

Drug Combinations*
Drug Therapy, Combination / methods*
Humans
Pulmonary Arterial Hypertension / drug therapy*

Substances

Drug Combinations