Role of bioactive metabolites from Acremonium camptosporum associated with the marine sponge Aplysina fulva

Thamires Martins; Claudia Schinke; Sonia C N Queiroz; Patrícia A de C Braga; Fábio S P Silva; Itamar S Melo; Felix G R Reyes

doi:10.1016/j.chemosphere.2021.129753

Role of bioactive metabolites from Acremonium camptosporum associated with the marine sponge Aplysina fulva

Chemosphere. 2021 Jul:274:129753. doi: 10.1016/j.chemosphere.2021.129753. Epub 2021 Jan 22.

Authors

Thamires Martins¹, Claudia Schinke², Sonia C N Queiroz³, Patrícia A de C Braga⁴, Fábio S P Silva⁵, Itamar S Melo⁶, Felix G R Reyes⁷

Affiliations

¹ Department of Food Science, School of Food Engineering, University of Campinas, Campinas, SP, 13083-862, Brazil. Electronic address: martins_thamires@hotmail.com.
² Department of Food Science, School of Food Engineering, University of Campinas, Campinas, SP, 13083-862, Brazil. Electronic address: claudia_schinke@yahoo.com.br.
³ Brazilian Agricultural Research Corporation, Embrapa Environment, Jaguariúna, SP, 13820-000, Brazil. Electronic address: sonia.queiroz@embrapa.br.
⁴ Department of Food Science, School of Food Engineering, University of Campinas, Campinas, SP, 13083-862, Brazil. Electronic address: pbraga2015@gmail.com.
⁵ Brazilian Agricultural Research Corporation, Embrapa Environment, Jaguariúna, SP, 13820-000, Brazil. Electronic address: fabiopaul@gmail.com.
⁶ Brazilian Agricultural Research Corporation, Embrapa Environment, Jaguariúna, SP, 13820-000, Brazil. Electronic address: itamar.melo@embrapa.br.
⁷ Department of Food Science, School of Food Engineering, University of Campinas, Campinas, SP, 13083-862, Brazil. Electronic address: reyesfgr@unicamp.br.

PMID: 33540315
DOI: 10.1016/j.chemosphere.2021.129753

Abstract

Acremonium camptosporum, a fungus associated with the marine sponge Aplysina fulva, was collected from the isolated mid-Atlantic Saint Peter and Saint Paul Archipelago, Brazil, and was found to produce secondary metabolites that displayed antibacterial activities. Mass spectra data obtained by UPLC-ESI-MS/MS analyses of these extracts were compared to several databases and revealed the presence of several different cytotoxic acremonidins and acremoxanthones. The close association between the sponge and the fungi with its compounds could be of strategic importance in defending both from the high predation pressure and spatial competition in the warm-water scarps of the islands.

Keywords: Acremonidin; Acremoxanthone; Fungi; Predation pressure; UPLC-ESI-MS/MS.

MeSH terms

Acremonium*
Animals
Brazil
Islands
Porifera*
Tandem Mass Spectrometry

Supplementary concepts

Acremonium camptosporum