Glycomacromolecules: Addressing challenges in drug delivery and therapeutic development

Abstract

Carbohydrate-based materials offer exciting opportunities for drug delivery. They present readily available, biocompatible components for the construction of macromolecular systems which can be loaded with cargo, and can enable targeting of a payload to particular cell types through carbohydrate recognition events established in biological systems. These systems can additionally be engineered to respond to environmental stimuli, enabling triggered release of payload, to encompass multiple modes of therapeutic action, or to simultaneously fulfil a secondary function such as enabling imaging of target tissue. Here, we will explore the use of glycomacromolecules to deliver therapeutic benefits to address key health challenges, and suggest future directions for development of next-generation systems.

Keywords: Biofilms; Biopolymers; Cancer; Carbohydrates; Drug delivery systems; Nanomedicine; Nanoparticles; Receptor mediated targeting; Stimuliresponsive drug delivery systems; Theranostics; siRNA delivery.