Single-agent cladribine as an effective front-line therapy for adults with Langerhans cell histiocytosis

Am J Hematol. 2021 May 1;96(5):E146-E150. doi: 10.1002/ajh.26119. Epub 2021 Feb 19.

Authors

Gaurav Goyal^{1

2}, Jithma P Abeykoon³, Marie Hu⁴, Jason R Young⁵, Mithun V Shah³, N Nora Bennani³, Timothy G Call³, C Christopher Hook³, Animesh Pardanani³, David J Inwards³, Robert Vassallo⁶, Jay H Ryu⁶, W Oliver Tobin⁷, Matthew J Koster⁸, Caroline J Davidge-Pitts⁹, Aishwarya Ravindran¹⁰, Karen L Rech¹⁰, Ronald S Go⁴; Mayo Clinic-University of Alabama at Birmingham Histiocytosis Working Group

Affiliations

¹ Division of Hematology-Oncology, University of Alabama at Birmingham, Birmingham, Alabama.
² Research Collaborator, Division of Hematology, Mayo Clinic, Rochester, Minnesota.
³ Division of Hematology, Mayo Clinic, Rochester, Minnesota.
⁴ Department of Hematology, Oncology, and Transplant, University of Minnesota, Minneapolis, Minnesota.
⁵ Department of Radiology, Mayo Clinic, Rochester, Minnesota.
⁶ Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota.
⁷ Department of Neurology, Mayo Clinic, Rochester, Minnesota.
⁸ Division of Rheumatology, Mayo Clinic, Rochester, Minnesota.
⁹ Division of Endocrinology, Diabetes, and Nutrition, Mayo Clinic, Rochester, Minnesota.
¹⁰ Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural

MeSH terms

Adult
Aged
Cladribine / administration & dosage
Cladribine / pharmacology
Cladribine / therapeutic use*
Combined Modality Therapy
Disease Progression
Drug Evaluation
Female
Histiocytosis, Langerhans-Cell / diagnostic imaging
Histiocytosis, Langerhans-Cell / drug therapy*
Histiocytosis, Langerhans-Cell / physiopathology
Histiocytosis, Langerhans-Cell / therapy
Humans
Kaplan-Meier Estimate
MAP Kinase Signaling System / drug effects
Magnetic Resonance Imaging
Male
Middle Aged
Mutation, Missense
Point Mutation
Positron Emission Tomography Computed Tomography
Progression-Free Survival
Proto-Oncogene Proteins B-raf / genetics
Pulmonary Diffusing Capacity / drug effects
Retrospective Studies
Treatment Outcome
Young Adult

Substances

Cladribine
BRAF protein, human
Proto-Oncogene Proteins B-raf

Grants and funding