Cytochrome P450 reductase (POR) as a ferroptosis fuel

Protein Cell. 2021 Sep;12(9):675-679. doi: 10.1007/s13238-021-00823-0. Epub 2021 Feb 4.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Membrane / metabolism
  • Coenzyme A Ligases / genetics*
  • Coenzyme A Ligases / metabolism
  • Cytochrome P-450 Enzyme System / genetics*
  • Cytochrome P-450 Enzyme System / metabolism
  • Cytochrome-B(5) Reductase / genetics
  • Cytochrome-B(5) Reductase / metabolism
  • Endoplasmic Reticulum / metabolism
  • Eukaryotic Cells / cytology
  • Eukaryotic Cells / metabolism
  • Fatty Acids, Unsaturated / metabolism
  • Ferroptosis / genetics*
  • Gene Expression Regulation
  • Humans
  • Iron / metabolism
  • Lipid Peroxidation / genetics*
  • Lipid Peroxides / metabolism*
  • Oxygen / metabolism

Substances

  • Fatty Acids, Unsaturated
  • Lipid Peroxides
  • POR protein, human
  • Cytochrome P-450 Enzyme System
  • Iron
  • CYB5R1 protein, human
  • Cytochrome-B(5) Reductase
  • Coenzyme A Ligases
  • long-chain-fatty-acid-CoA ligase
  • Oxygen