Two new bioactive secondary metabolites from the endophytic fungus Talaromyces assiutensis JTY2

Ying-Li Li; Ji-Ling Yi; Jin Cai; Xue-Ming Zhou; Li Chen; Xin Zhuo; Xin-Yi Lai

doi:10.1080/14786419.2021.1881961

Two new bioactive secondary metabolites from the endophytic fungus Talaromyces assiutensis JTY2

Nat Prod Res. 2022 Jul;36(14):3695-3700. doi: 10.1080/14786419.2021.1881961. Epub 2021 Feb 4.

Authors

Ying-Li Li^{1

2}, Ji-Ling Yi^{1

2}, Jin Cai^{1

2}, Xue-Ming Zhou^{1

2}, Li Chen^{1

2}, Xin Zhuo^{1

2}, Xin-Yi Lai^{1

2}

Affiliations

¹ Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, P.R. China.
² Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, P.R. China.

PMID: 33538208
DOI: 10.1080/14786419.2021.1881961

Abstract

One new lactone derivative helicascolide F (1), one new pyrrolidine derivative talaromydine (2), along with six known compounds (3-8) were isolated from the fungus Talaromyces assiutensis JTY2. The structure of the new compounds 1 and 2 was determined by 1D and 2D NMR as well as by HRESIMS. The inhibitory activity of all compounds against six phytopathogenic fungi and three cancer cell lines was evaluated.

Keywords: Talaromyces assiutensis; antifungal; cytotoxic; lactone derivatives; pyrrolidine derivatives.

MeSH terms

Magnetic Resonance Spectroscopy
Molecular Structure
Talaromyces* / chemistry

Supplementary concepts

Talaromyces assiutensis