Abstract
Recently, coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 has spread around the world and is receiving worldwide attention. Approximately 20% of infected patients are suffering from severe disease of multiple systems and in danger of death, while the ocular complications of SARS-CoV-2-infected patients have not been reported generally. Herein, we focus on two major receptors of SARS-CoV-2, ACE2 and CD147 (BSG), in human ocular cells, and interpret the potential roles of coronaviruses in human ocular tissues and diseases.
Keywords:
ACE2; BSG; CD147; COVID-19; Coronavirus; Eye; RAS; SARS-CoV-2.
Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Angiotensin-Converting Enzyme 2 / chemistry
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Angiotensin-Converting Enzyme 2 / metabolism
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Animals
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Antirheumatic Agents / therapeutic use
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Basigin / metabolism
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COVID-19 / pathology*
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COVID-19 / transmission
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COVID-19 / virology
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COVID-19 Drug Treatment
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Dexamethasone / therapeutic use
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Eye / cytology
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Eye / metabolism
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Eye / virology*
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Eye Diseases / pathology
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Eye Diseases / virology
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Glucocorticoids / therapeutic use
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Humans
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Renin-Angiotensin System / physiology
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SARS-CoV-2 / isolation & purification
Substances
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Antirheumatic Agents
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BSG protein, human
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Glucocorticoids
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Basigin
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Dexamethasone
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ACE2 protein, human
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Angiotensin-Converting Enzyme 2