Eyes on coronavirus

Stem Cell Res. 2021 Mar:51:102200. doi: 10.1016/j.scr.2021.102200. Epub 2021 Jan 27.

Abstract

Recently, coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 has spread around the world and is receiving worldwide attention. Approximately 20% of infected patients are suffering from severe disease of multiple systems and in danger of death, while the ocular complications of SARS-CoV-2-infected patients have not been reported generally. Herein, we focus on two major receptors of SARS-CoV-2, ACE2 and CD147 (BSG), in human ocular cells, and interpret the potential roles of coronaviruses in human ocular tissues and diseases.

Keywords: ACE2; BSG; CD147; COVID-19; Coronavirus; Eye; RAS; SARS-CoV-2.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiotensin-Converting Enzyme 2 / chemistry
  • Angiotensin-Converting Enzyme 2 / metabolism
  • Animals
  • Antirheumatic Agents / therapeutic use
  • Basigin / metabolism
  • COVID-19 / pathology*
  • COVID-19 / transmission
  • COVID-19 / virology
  • COVID-19 Drug Treatment
  • Dexamethasone / therapeutic use
  • Eye / cytology
  • Eye / metabolism
  • Eye / virology*
  • Eye Diseases / pathology
  • Eye Diseases / virology
  • Glucocorticoids / therapeutic use
  • Humans
  • Renin-Angiotensin System / physiology
  • SARS-CoV-2 / isolation & purification

Substances

  • Antirheumatic Agents
  • BSG protein, human
  • Glucocorticoids
  • Basigin
  • Dexamethasone
  • ACE2 protein, human
  • Angiotensin-Converting Enzyme 2