Bisabolanoic acid A, a new polychiral sesquiterpene with AChE inhibitory activity from a mangrove-derived fungus Colletotrichum sp

J Asian Nat Prod Res. 2022 Jan;24(1):88-95. doi: 10.1080/10286020.2021.1873297. Epub 2021 Feb 3.

Abstract

A new polychiral bisabolane sesquiterpene, bisabolanoic acid A (1), was isolated from the mangrove-derived fungus Colletotrichum sp. SCSIO KcB3-2. Its planar structure was identified on the basis of spectroscopic data analysis (HRESIMS, 1D, and 2D NMR), and the absolute configurations of three chiral carbons were determined by experimental and calculated electronic circular dichroism (ECD) and optical rotatory dispersion (ORD), together with Mo2(OAc)4-induced ECD methods. Bisabolanoic acid A (1) showed moderate inhibitory activity against acetylcholinesterase (AChE) with IC50 value of 2.2 μM, and the in silico molecular docking was also performed.

Keywords: AChE inhibitory; Bisabolanoic acid A; absolute configuration; mangrove-derived fungus.

MeSH terms

  • Acetylcholinesterase
  • China
  • Cholinesterase Inhibitors*
  • Colletotrichum* / chemistry
  • Molecular Docking Simulation
  • Molecular Structure
  • Rhizophoraceae / microbiology*
  • Sesquiterpenes* / pharmacology

Substances

  • Cholinesterase Inhibitors
  • Sesquiterpenes
  • Acetylcholinesterase