Two coordination polymers, namely [Ag2(L)(SO3CF3)(H2O)](SO3CF3)•CH2Cl2 (1) and [Ag5(L)4(H2O)2](SbF6)5•5THF (2), were obtained by reacting oxadiazole-containing tri-armed ligand 1,3,5-tri(2-methylthio-1,3,4-oxadiazole-5yl) ben-zene (L) and silver salts in CH2Cl2/THF medium. The two complexes crystallized in the tetragonal space group I41/a and orthorhombic space group Fdd2, respectively. The Single-crystal X-ray diffraction revealed that the two complexes ex-hibit strikingly different 3D polymeric structures, which can be ascribed to the different counter anions. L in compound 1 acted as a hexa-dentate ligand, binding to two types of Ag+ atoms to form a 3D polymeric structure. L in compound 2acted as a hexa- and penta-dentate ligand, binding to three types of Ag+ atoms to form the 3D polymeric structure. The antibacterial activity of the complexes was also investigated.