Association between Baseline SBP/DBP and All-Cause Mortality in Residents of Shanxi, China: A Population-based Cohort Study from 2002 to 2015

Zhuo Qun Wang; Yi Zhai; Man Li; Xiu Feng Yang; Jian Zhang; Ze Ping Ren; Mei Zhang; Peng Kun Song; Yan Fang Zhao; Sheng Quan Mi; Lu Zhang; Mao Xiang Yang; Wen Hua Zhao

doi:10.3967/bes2021.002

Association between Baseline SBP/DBP and All-Cause Mortality in Residents of Shanxi, China: A Population-based Cohort Study from 2002 to 2015

Biomed Environ Sci. 2021 Jan 20;34(1):1-8. doi: 10.3967/bes2021.002.

Authors

Zhuo Qun Wang¹, Yi Zhai², Man Li³, Xiu Feng Yang⁴, Jian Zhang⁵, Ze Ping Ren⁶, Mei Zhang¹, Peng Kun Song⁵, Yan Fang Zhao¹, Sheng Quan Mi⁷, Lu Zhang³, Mao Xiang Yang⁴, Wen Hua Zhao⁵

Affiliations

¹ National Center for Chronic and Noncommunicable Disease Control and Prevention, China CDC, Beijing 100050, China.
² Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Beijing 100070, China.
³ Hebei Key Laboratory of Environment and Human Health, Department of Epidemiology and Statistic, Hebei Medical University, Shijiazhuang 050017, Hebei, China.
⁴ Xinfu Center for Disease Control and Prevention, Xinfu 034000, Shanxi, China.
⁵ National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
⁶ Shanxi Center for Disease Control and Prevention, Taiyuan 030012, Shanxi, China.
⁷ College of Biochemical Engineering, Beijing Union University, Beijing 100023, China.

PMID: 33531102
DOI: 10.3967/bes2021.002

Abstract

Objective: To investigate the association between blood pressure and all-cause mortality in Shanxi, China.

Methods: The '2002 China Nutrition and Health Survey' baseline data in Shanxi province was used. A retrospective investigation was performed in 2015. The effects of SBP and DBP on the all-cause mortality were analyzed using the Cox regression model. The hazard ratio ( HR) and 95% confidence interval ( CI) were estimated by the sex and age groups.

Results: The follow-up rate was 76.52% over 13 years, while the cumulative mortality rate for all participants was 917.12/100,000 person-years. The mortality rose with an increasing SBP ( χ ² _trend = 270.537, P < 0.001) or DBP level ( χ ² _trend = 57.240, P < 0.001). After adjustment for the confounding factors, a significant association between mortality and high SBP (≥ 160 mmHg) and high DBP (≥ 100 mmHg), with adjusted HR ranging from 1.405- to 2.179-fold for SBP and 1.550- to 2.854-fold for DBP, was noted. Significant HRs for most DBP subgroups were found in > 60-year-old participants. Males with DBP ≥ 100 mmHg had a significantly higher mortality, with an HR (95% CI) of 2.715 (1.377-5.351).

Conclusion: Adults with SBP > 160 mmHg and DBP > 100 mmHg had a higher mortality risk. Sex and age difference was noted in both DBP and mortality risk.

Keywords: Blood pressure; Cohort study; Hazard ratio; Mortality; Shanxi province.

MeSH terms

Adolescent
Adult
Aged
Blood Pressure
China
Cohort Studies
Female
Health Surveys
Humans
Hypertension / mortality*
Male
Middle Aged
Mortality / trends*
Proportional Hazards Models
Young Adult