The Role of Biosynthesized Silver Nanoparticles in Antimicrobial Mechanisms

Curr Pharm Biotechnol. 2021;22(6):762-772. doi: 10.2174/1389201022666210202143755.

Abstract

Nanotechnology is an area of science in which new materials are developed. The correlation between nanotechnology and microbiology is essential for the development of new drugs and vaccines. The main advantage of combining these areas is to associate the latest technology in order to obtain new ways for solving problems related to microorganisms. This review seeks to investigate nanoparticle formation's antimicrobial properties, primarily when connected to the green synthesis of silver nanoparticles. The development of new sustainable methods for nanoparticle production has been instrumental in designing alternative, non-toxic, energy-friendly, and environmentally friendly routes. In this sense, it is necessary to study silver nanoparticles' green synthesis concerning their antimicrobial properties. Antimicrobial silver nanoparticles' mechanisms demonstrate efficiency to gram-positive bacteria, gram-negative bacteria, fungi, viruses, and parasites. However, attention is needed with the emergence of resistance to these antimicrobials. This article seeks to relate the parameters of green silver- based nanosystems with the efficiency of antimicrobial activity.

Keywords: Silver nanoparticles; applications; biotechnology; green synthesis; nanosystems; nanotechnology antimicrobial mechanisms.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Bacterial Agents / pharmacology
  • Anti-Infective Agents / pharmacology*
  • Fungi / drug effects
  • Gram-Negative Bacteria / drug effects
  • Gram-Positive Bacteria / drug effects
  • Metal Nanoparticles / chemistry*
  • Parasites / drug effects
  • Silver / chemistry*
  • Viruses / drug effects

Substances

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Silver